Monoclonal antibodies against antithrombin [beta]

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专利权人:

BAYER HEALTHCARE LLC

发明人:

JIN, YE,MURPHY, JOHN,HERMISTON, TERRY,MYLES, TIMOTHY,DITTMER, FRANK,STRERATH, MICHAEL,GRITZAN, UWE

申请号：

TW103109449

公开号：

TW201529602A

申请日:

2014.03.14

申请国别(地区):

TW

年份:

2015

代理人:

摘要：

This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin [beta] complexed with heparin and/or heparin-like structure (AT[beta]H). These AT[beta]H binding proteins can block the anti-coagulant activity of AT[beta] to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.

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