Disclosed are systems, devices, and methods for planning a procedure for treatment of lung tissue. An exemplary method includes generating a three-dimensional (3D) model of the luminal network, displaying the 3D model of the luminal network, selecting a target location in the tissue adjacent to the luminal network as displayed on the 3D model, identifying a point in the luminal network which is proximate to or at the target location, determining an access path between the target location and the identified point in the luminal network, calculating a risk of injury to intervening structures between the target location and the identified point in the luminal network, based on the determined access path, and displaying the access path and the calculated risk of injury for the access path on the 3D model.
