PROCÉDÉ DE FABRICATION D'UNE SUBSTANCE CONTENANT DE LA NOBILÉTINE ET DE LA TANGÉRÉTINE DÉRIVÉES DE FRUITS D'AGRUMES, ET SUBSTANCE CONTENANT DE LA NOBILÉTINE ET DE LA TANGÉRÉTINE AINSI OBTENUE
The object of the invention is to provide a method of manufacturing a fraction containing nobiletin and tangeretin at high concentrations, which is excellent in terms of safety, economic efficiency, and the potential for industrialization. The object is achieved by a method of manufacturing a composition containing nobiletin and tangeretin, comprising (1-1) a step of treating citrus fruit with hot water to obtain a hot water-treated product； (1-2) a step of drying the hot water-treated product to obtain a dried product； (1-3) a step of treating the dried product with a solvent capable of dissolving nobiletin and tangeretin to obtain a nobiletin and tangeretin solution； (3) a step of concentrating and/or drying the nobiletin and tangeretin solution to obtain a nobiletin and tangeretin concentrate； and (4) a step of treating the nobiletin and tangeretin concentrate with a dilute alkali to obtain a composition containing nobiletin and tangeretin as an insoluble component, and by a composition containing nobiletin and tangeretin at high concentrations manufactured by the method.
