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APPLICATION OF ANALYSIS IN RADIO STABILIZATION OF OXIMAL LIGATION REACTIONS
专利权人:
ДжиИ Хелткер Лимитед (GB)
发明人:
ЭНГЕЛЛЬ Торгрим (NO),ОСБОРН Найджел (GB)
申请号:
RU2013128354/04
公开号:
RU2013128354A
申请日:
2011.12.15
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method of radio stabilization, comprising the step of reacting a radioactive isotope-labeled aldehyde (I) with aminooxy (II) in the presence of aniline (III) to form imine-oxy (IV) :. 2. The radio stabilization method according to claim 1, wherein said radioactive isotope-labeled aldehyde (I) is a compound of formula (VIII): wherein is a radioactive isotope-labeled organic or biological moiety. The radio stabilization method according to claim 2, wherein said radioactive isotope-labeled organic moiety is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocyclyl, heteroaryl or cycloalkyl, and wherein said radioactive isotope-labeled biological moiety is an amino acid, peptide or vector. A radio stabilization method according to any one of claims 1 to 3, wherein the radioactive label is a radioactive isotope suitable for imaging by PET (positron emission tomography) or SPECT (single photon emission computed tomography) .5. The radio stabilization method according to claim 1, wherein said radioactive isotope-labeled aldehyde is [18F] para-benzaldehyde. The radio stabilization method according to claim 1, wherein said aminooxy (II) is a compound of formula (IX): wherein R2 may be any organic or biological moiety. The radio stabilization method according to claim 6, wherein said aminooxy (II) is or. The radio stabilization method according to claim 1, wherein said imine-hydroxy-labeled radioactive isotope is a compound of formula (X) :. 9. A radio stabilization method comprising the step of reacting an aldehyde (V) with radiolabelled and1. Способ радиостабилизации, включающий стадию взаимодействия меченного радиоактивным изотопом альдегида (I) с аминоокси (II) в присутствии анилина (III) с образованием имин-окси (IV):.2. Способ радиостабилизации по п.1, где указанный меченный радиоактивным изотопом альдегид (I) представляет собой соединение формулы (VIII):гдепредставляет собой меченную радиоактивным изотопом органическую или биологическую группировку.3. Способ радиост
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