LUYTEN, FRANK,DE BARI, COSIMO,DELL'ACCIO, FRANCESCO
申请号：
CA2397610
公开号：
CA2397610C
申请日:
2000.10.06
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
An in vivo assay to measure anchorage-independent growth and phenotypicstability of a certain cell population comprising subcutaneous orintramuscular injection in a mammal of a cell suspension of articularchondrocytes in an iso-osmotic liquid, the same suspension comprisingarticular chondrocytes in an amount equivalent to at least 1 x 106chondrocytes as applied to immune-deficient mice. The outcome is linked tomolecular markers. The present invention further relates to DNA chips anddiagnostic tools comprising the latter to predict the outcome of ACT.Antibodies raised against positive and negative markers of chondrocytestability can also be used for quality control on the chondrocytes.Therapeutical composition comprising stable chondrocytes are very useful fortissue repair.
