CARTER, DAVID SCOTT,DILLON, MICHAEL PATRICK,HAWLEY, RONALD CHARLES,LIN, CLARA,PARISH, DANIEL WARREN,BROKA, CHRIS ALLEN,JAHANGIR, ALAM
申请号：
ES05715558
公开号：
ES2391636T3
申请日:
2005.02.25
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein: X is -O- Y is hydrogen or -NR d R e wherein one of Rd and Re is hydrogen and the other is hydrogen I rent cycloalkyl cycloalkylalkyl haloalkyl haloalkoxy hydroxyalkyl alkoxyalkyl acetyl alkylsulfonyl I alkylsulfonylalkyl I aminocarbonyloxyalkyl hydroxycarbonyl hydroxyalkyloxycarbonylalkyl aryl aralkyl arylsulfonyl heteroaryl heteroarylalkyl heteroarylsulfonyl heterocyclyl or heterocyclylalkyl D is an optional oxygen R1 is isopropyl, R2, R4 and R5 each independently are hydrogen I rent alkenyl Not me halogen amido haloalkyl alkoxy, hydroxy haloalkoxy nitro Not me hydroxyalkyl alkoxyalkyl hydroxyalkoxy alquinilalcoxi alkylsulfonyl arylsulfonyl cyano aryl heteroaryl heterocyclyl heterocyclylalkoxy aryloxy heteroaryloxy aralkyloxy heteroaralkyloxy optionally substituted phenoxy - (CH2) m- (Z) n- (CO) -Rf or - (CH2) m- (Z) n-SO2- (NRg) n-Rf in losque m and n are independently 0 or 1, Z is O or NR g, R f is hydrogen, alkyl, hydroxy, alkoxy, amino, hydroxyalkyl or alkoxyalkyl, and each Rg independently of its occurrence is hydrogen or alkyl R3 is methoxy R6 is hydrogen I rent halogen haloalkyl Not me or alkoxy yuno of R7 and R8 is hydrogen and the other is hydrogen I rent cycloalkyl cycloalkylalkyl haloalkyl haloalkoxy hydroxyalkyl alkoxyalkyl acetyl alkylsulfonyl I alkylsulfonylalkyl aminocarbonyloxyalkyl hydroxycarbonyl hydroxyalkyloxycarbonylalkyl aryl aralkyl arylsulfonyl heteroaryl heteroarylalkyl heteroarylsulfonyl heterocyclyl or heterocyclylalkyl.Un compuesto de la fórmula (I)o una sal farmacéuticamente aceptable del mismo,en la que:X es -O-Y es hidrógeno o -NRdRe en el que uno de Rd y Re es hidrógeno y el otro es hidrógeno alquilo cicloalquilocicloalquilalquilo haloalquilo haloalcoxi hidroxialquilo alcoxialquilo acetilo alquilsulfonilo alquilsulfonilalquilo aminocarboniloxialquilo hidroxicarbonilalquilo hidroxialquiloxicarbonilalquilo arilo aralquiloarilsulfonilo heteroarilo heteroar
