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New hexahydropyrroloimidazolone compounds
专利权人:
F. Hoffmann-La Roche AG
发明人:
CONTE, Aurelia,HUNZIKER, Daniel,NEIDHART, Werner,NETTEKOVEN, Matthias,SCHULZ-GASCH, Tanja
申请号:
ES12719369
公开号:
ES2571539T3
申请日:
2012.05.04
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Compounds of the formula (I) ** Formula ** in which: R 1 is alkyl, haloalkyl, alkoxyalkyl, haloalkoxyalkyl, hydroxyalkyl, phenyl, substituted phenyl, phenylalkyl, substituted phenylalkyl, phenoxyalkyl, substituted phenoxyalkyl, heteroaryl, substituted heteroaryl, heteroaryl substituted heteroarylalkyl, said substituted phenyl, substituted phenylalkyl, substituted phenoxyalkyl, substituted heteroaryl and substituted heteroarylalkyl are substituted one to three times by substituents independently selected from alkyl, cycloalkyl, cycloalkylalkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkoxy , hydroxyhaloalkyl and alkoxyhaloalkyl; R2 is phenyl, substituted phenyl, heteroaryl or substituted heteroaryl, said substituted phenyl and substituted heteroaryl are substituted one to three times by substituents independently selected from alkyl, cycloalkyl, cycloalkylalkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, haloalkoxy , hydroxyhaloalkyl and alkoxyhaloalkyl; R3 is hydrogen, hydroxy or alkoxy, in case R3 is hydroxy or alkoxy, then A is a bond; R4 is hydrogen, alkyl or cycloalkyl; R5 is hydrogen, alkyl or cycloalkyl; A is -O-, -OC (O) -, -NR4C (O) O-, -NR4-, -C (O) NR4-, -NR4C (O) NR5-, -S (O) 2NR4-, - NR4S (O) NR5-, -NR4S (O) 2NR5-, -S-, -S (O) -, -S (O) 2- or a link, in case A is a link, then R1 is alkoxyalkyl or haloalkoxyalkyl; or pharmaceutically acceptable salts thereof.Compuestos de la fórmula (I)**Fórmula** en la que: R1 es alquilo, haloalquilo, alcoxialquilo, haloalcoxialquilo, hidroxialquilo, fenilo, fenilo sustituido, fenilalquilo, fenilalquilo sustituido, fenoxialquilo, fenoxialquilo sustituido, heteroarilo, heteroarilo sustituido, heteroarilalquilo o heteroarilalquilo sustituido, dichos fenilo sustituido, fenilalquilo sustituido, fenoxialquilo sustituido, heteroarilo sustituido y heteroarilalquilo sustituido están sustituidos de una a tres veces por sustituyentes elegidos con independencia entre alquilo, cicloalquilo, cic
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