Compound of formula II for use to increase the expression of ApoA-I in a mammal: ** Formula ** in which: X is N； R1 and R3 are each independently selected from alkoxy and hydrogen； R2 is selected from alkoxy, alkyl and hydrogen； R6 and R8 are each independently selected from alkyl, alkoxy, chloride and hydrogen； R4 and R5 are hydrogen； R7 is selected from amino, hydroxyl, alkoxy and alkyl substituted with a heterocyclyl, or two adjacent substituents selected from R6, R7 and R8 are connected to form a heterocyclyl； each W is independently selected from C and N； p is 1, with the exception that when W is N, then p is 0； wherein the "alkyl", "alkenyl", "alkynyl", "alkoxy", "amino" and "amide" groups may be substituted with or interrupted by or branched with at least one group selected from alkoxy, aryloxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxyl, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydroxyl, ketone, nitro, phosphate, sulphide, sulfinyl, sulfonyl, sulfonic acid , sulfonamide, thioketone, ureido and N； with the proviso that if R2 is selected from alkoxy or hydrogen, then at least one of R1 and R3 is alkoxy； with the proviso that if R7 is selected from hydroxyl or alkoxy, then at least one of R6 and R8 is independently selected from alkyl, alkoxy and chloride； with the proviso that if for W- (R7) p, W is N and p is 0, then at least one of R6 and R8 is chloride； and pharmaceutically acceptable salts and hydrates thereof.Compuesto de fórmula II para su uso para aumentar la expresión de ApoA-I en un mamífero: **Fórmula** en la que: X es N； R1 y R3 se seleccionan cada uno independientemente de alcoxilo e hidrógeno； R2 se selecciona de alcoxilo, alquilo e hidrógeno； R6 y R8 se seleccionan cada uno independientemente de alquilo, alcoxilo, cloruro e hidrógeno； R4 y R5 son hidrógeno； R7 se selecciona de amino, hidroxilo, alcoxilo y alquilo sustituido con un heterociclilo, o dos sustituyentes ady
