Referred to a Conjugate of formula I, wherein the Linker is Blender or its derivativePreferably Antibody l is a Linker kN is an integer from 1 to 50, is an inhibitor of the KSP kinesin Spindle Protein or its prodrug, formula IIA,Where is where X1, x2 and X3 is is n c, among others r1 is H, halogen, among others R2 is # - L - H, - 1, mod, among others R4 is # - L - 1, h, among others R3 is # - L - 1 mod, rent,Among others, R5 is H, NH2, NO2, among others R6 and R7 are, independently of one another, N - alkyl, cyano, C1, among others R8 is C1 - 10 (Fluorinated Alkyl eventually)Alquenilo C2 - 10 (or fluoride), among others R9 IS F, h, CH3, among others is co, SO2, so,So2nh or cnnh where # 1 - l is the link with the Linker or its derivative - mod is (NR10) - N - (G1 and G2) - - H n is 0 OR 1 or is 0 OR 1 R10 is H or alkyl C1 G1 is - NH - 3 C (= o),Among others, G2 is a straight chain Hydrocarbon and \/ or branched with 1 to 10 carbon ATOMS, among others. It also refers to methods for preparing such Conjugates.These conjugated Linker ligation or prodrug (APDC) - Active Principle (ADC), are useful in the treatment of proliferative diseases such as cancer.Referido a un conjugado de formula I, en donde el LIGADOR es ligador o su derivado, preferentemente anticuerpo L es un enlazador kn es un numero entero de 1 a 50 KSP es un inhibidor de la proteina de huso de la quinesina o de su profarmaco, de formula IIa, en donde en donde X1 es N, X2 es N y X3 es C, entre otros R1 es H, halogeno, entre otros R2 es -L-#1, H, -MOD, entre otros R4 es -L-#1, H, entre otros R3 es -L-#1, MOD, alquilo, entre otros R5 es H, NH2, NO2, entre otros R6 y R7 son, de modo independiente entre si, N, ciano, alquilo C1-10, entre otros R8 es alquilo C1-10 (eventualmente fluorado), alquenilo C2-10 (eventualmente fluorado), entre otros R9 es H, F, CH3, entre otros A es CO, SO, SO2, SO2NH o CNNH en donde -L#1 es el enlace con el ligador o su derivado -MOD es -(NR10)n-(G1)o-G2-H n es 0 o 1 o es 0 o 1 R10 es
