The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like； A is lower alkylene； Ring X is optionally substituted arylene； E is bond or lower alkenylene； Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group； G is &mdash；NH-G2-, &mdash；N(lower alkyl)-G2-, &mdash；NH&mdash；CH2-G2-, &mdash；N(lower alkyl)-CH2-G2- or &mdash；CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O&mdash；R2, phenylene-G5-NH&mdash；R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O&mdash；R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents； G3-R2 is &mdash；O-lower alkylene-R2 or the like； G4-O&mdash； is lower alkylene-O&mdash； or the like； G5 is lower alkylene； G6 is lower alkylene].
