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Pyridine derivatives
专利权人:
Astellas Pharma Inc.;Kotobuki Pharmaceutical Co., Ltd.
发明人:
KAWAGUCHI, Kenichi,ISHIHATA, Akihiro,KANAI, Akira,TSUCHIYA, Kazuyuki,INAGAKI, Yusuke,KAZAMI, Junichi,MORIKAWA, Hiroshi,HIRAMOTO, Masashi,ENJO, Kentaro,TAKAMATSU, Hajime
申请号:
ES15865019
公开号:
ES2755476T3
申请日:
2015.12.04
申请国别(地区):
ES
年份:
2020
代理人:
摘要:
Compound of formula (I) or a salt thereof: ** Formula ** wherein R1 is C1-10 alkyl optionally having 1 to 5 substituents selected from the group G1; C2-10 alkenyl optionally having 1 to 5 substituents selected from the group G1; C2-10 alkynyl having optionally 1 to 5 substituents selected from the group G1; -C1-10alkylene-X- (C1-10alkyl optionally having 1 to 5 substituents selected from the group G1); R4; 5- or 6-membered heterocyclic group having 1-4 hetero atoms selected from oxygen and sulfur, and optionally having 1 to 5 substituents selected from the group G3; -C1-10alkylene; -C2-6-R4-alkenylene; -C1-10alkylene-X-R4; or -C1-10alkylene-X-C1-10alkylene-R4, or R1 forms, together with R21 or R22 in the pyridine ring attached thereto, a hydrocarbon ring fused with the pyridine ring, represented by any of the following Formulas (i) to (iv): ** Formula ** in which the hydrocarbon ring optionally has 1 to 4 substituents selected from the group consisting of C1-10 alkyl optionally having 1 to 5 substituents selected from the group G1, cycloalkyl optionally having 1 to 5 substituents selected from the group G2, -C1-10alkylene-R4 and -O-C1-10alkylene-R4, or the hydrocarbon ring optionally forms a spiro ring with C3-8 cycloalkane, R21 and R22 are the same or different and each is H; C1-10 alkyl optionally having 1 to 5 substituents selected from the group G1; -X-C1-10 alkyl; -X-halogen-C1-10 alkyl; cycloalkyl optionally having 1 to 5 substituents selected from the group G2; or -C1-10alkylene- (cycloalkyl having optionally 1 to 5 substituents selected from the group G2), R3 is C1-10 alkyl optionally having 1 to 5 substituents selected from the group G1; -C1-10alkylene-X- (C1-10alkyl optionally having 1 to 5 substituents selected from the group G1); -C1-10alkylene-X- (C2-10 alkenyl having optionally 1 to 5 substituents selected from the group G1); -C1-10alkylene- (cycloalkyl optionally having 1 to 5 substituents selected from the group G2); -C1-10alkylene-X- (cycloalkyl opt
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