LAMBERT, JOHN,O'LEARY, JAMES, J.,SCHINDLER, JOANNE ELIZABETH SARAH,WEITMAN, STEVEN,QIN, ALBERT,OLEARY, JAMES, J.
申请号：
EP10825683
公开号：
EP2490715A4
申请日:
2010.10.21
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
This invention relates to a method of treatment and dosing regimen for treating disease, such as cancer and mammalian tumors, wherein therapy with a cytotoxic drug is suitable, by the administration of an antibody-toxin conjugate, such as a maytansinoid toxin, by infusion at an initial infusion rate of 1 mg/min or lower on a schedule selected from the group consisting of: (1) an amount of at least about 90 mg/m2 on day 1 and day 8, every three weeks； (2) at least an amount of about 30 mg/m2 on day 1, day 2 and day 3, every three weeks； (3) at least an amount of about 45 mg/m2 on day 1, day 8, and day 15, every 4 weeks； and (4) at least an amount of about 45 mg/m2 on day 1, day 8 and day 15, every 3 weeks.
