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БЫСТРОРАСТВОРИМАЯ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ЛОРНОКСИКАМ
专利权人:
ЭББОТТ ХЕЛТКЕА ПРАЙВИТ ЛИМИТЕД (IN)
发明人:
БОЛДХАНЕ Санджай (IN),БХОКАРЕ Кулдип (IN),Др.ДЖАТХАР Шрипад (IN),ЭЛЛИОТ Джеральдин Энн (AU)
申请号:
RU2012131509/15
公开号:
RU2012131509A
申请日:
2010.12.21
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. instant pharmaceutical composition comprising: a. lornoxicam or a pharmaceutically acceptable salt thereof b. at least one alkalizing agent c. at least one organic acid and d. pharmaceutically acceptable excipients, wherein the weight ratio of lornoxicam and basifying (s) agent (s) ranges from about 1:43 to about 1:85, and the weight ratio of the basifying (s) agent (s) and organic (s) acid ( acid) is in the range of from about 3: 1 to about 100: 1, with 3 min of said composition is released at least 30% of lornoxicam and within 10 minutes of said composition is released at least 40% lornoksikama.2. A composition according to claim 1, wherein the plasma Tlornoksikama to said composition is less than 45 min.3. A composition according to claim 1, wherein Slornoksikama plasma to the composition after administration of a dose of 8 mg of lornoxicam is greater than 950 ng / ml.4. A composition according to claim 1, wherein the area under the concentration curve lornoxicam (0-10 minutes) to said composition after administration of a dose of 8 mg of lornoxicam from about 10 ng · h / mL to about 70 ng · h / ml.5. A composition according to claim 1, wherein the area under the concentration curve lornoxicam (0-20 minutes) to said composition after administration of a dose of 8 mg of lornoxicam from about 70 ng · h / mL to about 200 ng · h / ml.6. A composition according to claim 1, wherein the area under the concentration curve lornoxicam (0-30 minutes) to said composition after administration of a dose of 8 mg of lornoxicam from about 200 ng · h / mL to about 500 ng · h / ml.7. A composition according to claim 1, wherein the amount of lornoxicam or a pharmaceutically acceptable salt is a di1. Быстрорастворимая фармацевтическая композиция, содержащая:a. лорноксикам или его фармацевтически приемлемые солиb. по меньшей мере один подщелачивающий агентc. по меньшей мере одну органическую кислоту иd. фармацевтически приемлемые эксципиенты,в которой массовое соотношение лорноксик
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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