In one aspect, a method for treating a subject having a hyperproliferative disorder is disclosed, including administering to the subject a composition including: IPM, an IPM analog, or a pharmaceutically acceptable salt thereof in the dosage from about 70 mg/m2/day to about 160 mg/m2/day etoposide in the dosage up to about 100 mg/m2/day and one or more of carboplatin, cisplatin, oxaliplatin, picoplatin, or a combination thereof in the dosage of from AUC 2 mg/mL/min to AUC 7 mg/mL/min wherein the treatment does not result in a dose limiting toxicity.在一態樣中,揭示一種治療患有過度增生性病症之個體的方法,該方法包括向該個體投予包含以下之組成物:IPM、IPM類似物或其醫藥學上可接受之鹽,其劑量為約70 mg/m2/天至約160 mg/m2/天;依託泊苷,其劑量為至多約100 mg/m2/天;及卡鉑、順鉑、奧沙利鉑、吡鉑或其組合中之一或多者,其劑量為AUC 2 mg/mL/min至AUC 7 mg/mL/min;其中該治療不會導致劑量限制性毒性。
