HART STEPHEN,ALI SIMAK,PUFONG BORIS TUMI,PORTER ANDREW C. G.,BULUWELA LAKI,VAINIKKA SATU,JENKINSON JOHN DAVID,KANDA PATRICK
申请号：
US20080152175
公开号：
US2009082250(A1)
申请日:
2008.05.13
申请国别(地区):
美国
年份:
2009
代理人:
摘要：
A method for suppressing the expression of a selected gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
