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GENE EXPRESSION SYSTEM AND REGULATION THEREOF
专利权人:
发明人:
申请号:
EP15774027.5
公开号:
EP3126506A4
申请日:
2015.04.01
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention relates to a novel gene expression system comprising: a) a first nucleotide sequence encoding a fusion polypeptide of: a1) a destabilizing domain (DD) based on DHFR, and a2) a GTPcyclohydrolase 1 (GCH1) polypeptide, or a biologically active fragment or variant thereof and b) a second nucleotide sequence encoding a tyrosine hydroxylase (TH) polypeptide, or a biologically active fragment or variant thereof. The invention also relates to use of this gene expression system together with a ligand binding to a destabilizing domain (DD) based on dihydrofolate reductase (DHFR) for treatment of diseases associated with a reduced dopamine level, such as Parkinsons disease.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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