This invention, the bone quantity of the Frizzled receptor origin which is selected from the group which consists of Frizzled1, Frizzled2 and Frizzled7 of mammal origin, bone density and/or arrangement identity above amino acid arranging and 85% of cystein rich domain or the said domain outside the cell where it has bone strength increase action the possessing and the bone quantity, bone density and/or the mutant of the said domain which has bone strength increase action, the protein which is included, or, the vector which includes the nuclear acid which the said protein the cord/code is done, regards the medicine composition for bone diseased remedy which it contains as the active ingredient.この発明は、哺乳動物由来のFrizzled1 、Frizzled2及びFrizzled7からなる群から選択されるFrizzled受容体由来の骨量、骨密度及び/又は骨強度増加作用をもつ細胞外システインリッチドメイン、又は該ドメインのアミノ酸配列と85%以上の配列同一性を有しかつ骨量、骨密度及び/又は骨強度増加作用をもつ該ドメインの変異体、を含む蛋白質、或いは、該蛋白質をコードする核酸を含むベクター、を有効成分として含有する骨疾患治療用医薬組成物に関する。
