D. Victor Perlroth,Stephen A. Charles,James Aggen,Didler Benoit,Wayne To,Lidia Mosyak,Laura Lin,Justin Cohen,Tetsuya Ishino,William Somers
申请号：
US14753824
公开号：
US09840553B2
申请日:
2015.06.29
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides a dual VEGF/PDGF antagonist comprising a VEGF antagonist linked to a PDGF antagonist. The VEGF antagonist is an antibody to a VEGF or VEGFR or is a VEGFR extracellular trap segment (i.e., a segment from the extracellular region of one or more VEGFR receptors that inhibits binding of at least one VEGFR to at least one VEGF). The PDGF antagonist is an antibody to a PDGF or PDGFR or is a PDGFR extracellular trap segment (i.e., segment from the extracellular region of one or more PDGFRs, which inhibits binding of at least one PDGFR and at least one PDGF). The dual antagonist is preferably conjugated to a half-life extending moiety, such as a HEMA-PC polymer. The dual antagonist is particularly useful for treating wet aged related macular degeneration.
