JIANG, WEI-DONG,姜 伟东,姜 偉東,LIN, PEI HUA,林佩桦,林佩樺,TSENG, CHI LING,曾琪铃,曾琪鈴,姜 伟东,姜 偉東
申请号：
TW105120598
公开号：
TW201718641A
申请日:
2016.06.29
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
Provided are anti-vascular endothelial growth factor receptor 2 (VEGFR2) antibodies, and antigen binding fragments thereof. Also provided are isolated nucleic acid molecules that encode the anti-VEGFR2 antibodies or antigen binding fragments thereof, related expression vectors, and host cells. Provided are methods of making anti-VEGFR2 antibodies and antigen binding fragments thereof. Also provided are related pharmaceutical compositions comprising anti-VEGFR2 antibodies (or antigen binding fragments thereof) and methods of their use in the treatment of pathological conditions characterized by excessive angiogenesis.本發明提供抗血管內皮生長因子受體2(vascular endothelial growth factor receptor 2；VEGFR2)抗體及其抗原結合片段。亦提供編碼該等抗VEGFR2抗體或其抗原結合片段之經分離核酸分子、相關表現載體及宿主細胞。提供製備抗VEGFR2抗體及其抗原結合片段之方法。亦提供包括抗VEGFR2抗體(或其抗原結合片段)之相關醫藥組合物及其用於治療特徵在於過度血管生成之病理學病狀之方法。
