The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.本發明關於一種抗體或其抗原結合片段,其與人類第二型血管內皮生長因子受體(vascular endothelial growth factor receptor 2,VEGFR-2)結合。本發明亦關於一種於一需要個體中抑制VEGFR-2調控之訊息傳遞的方法、一種治療患有由VEGFR-2之活性及/或訊息傳遞所導致或與其相關聯疾病及/或失調之個體之方法、一種治療患有腫瘤之個體之方法、一種於一需要個體中抑制內皮細胞之細胞增生的方法及一種偵測一樣品中之人類第二型血管內皮生長因子受體的方法。
