ABBOTT LABORATORIES;ABBVIE DEUTSCHLAND GMBH & CO KG;ABBVIE INC.;ABBOTT GMBH & CO. KG
发明人:
TURNER, SEAN COLM,BAKKER, MARGARETHA HENRICA MARIA,STEWART, KENT D.
申请号：
ES07821595
公开号：
ES2445791T3
申请日:
2007.10.19
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A heterocyclic compound of the general formula (I) is the stereoisomers and / or physiologically acceptable acid addition salts thereof, whereA is selected from the group consisting of NH, N-C1-C4 alkyl and C1-C4 N-halogenated alkyl (preferably fluorinated)； X1 is N； X2 is selected from the group consisting of CH, CR2 and N； X3 is selected from the group consisting of CH, CR2 and N； X4, X5, X6 and X7 are independently selected from each other from the group consisting of CH, CR1 and N, Y3, Y4, Y5 and Y6 are independently selected from each other from the group consisting of a C, CH, CR3 and N, resulting in a 6-member C-ring； or one of Y3, Y4, Y5 and Y6 is part of the bridge bond between its two adjacent atoms that results in a 5-member C-ring； or with Y5>； = Y6>； = C, then Y5 and Y6 can form together with the ring of 5 or 6 members C, a fused cyclic ring having 5 or 6 ring members, including Y5 and Y6 as ring members and comprising atoms of C as ring members or instead of an atom of C may contain 0, 1, 2 or 3 members of heteroaromatic rings, independently selecting each other from the group consisting of N, O and S, where the condensed ring system it can be substituted with 1, 2 or 3 residues R3, independently having a meaning as defined below: n is the number of residues R3 and is selected from 0, 1, 2, 3 or 4； m is the number of residues R2 and is selected from 0, 1 or 2； or is the number of residues R1 and is selected from 0, 1, 2, 3 or 4； R1, R3 are independently selected from each other, and independently in each case, from the group consisting of NH2, NH-C1 alkyl -C6, NRaRb, OH,>； = O, C1-C6 alkoxy, C1-C6 haloalkoxy, halogen, C1-C4 alkyl, C3-C7 cycloalkyl, C2-C4 alkenyl, halogenated C1-C4 alkyl (preferably fluorinated), C3- cycloalkyl C7halogenated (preferably fluorinated), halogenated C2-C4 alkenyl (preferably fluorinated), formyl, C1-C6 alkylcarbonyl, C1-C6 alkyl-NRaRb and an aromatic radical Ar, which is selected from the group consisting of phenyl an
