Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broader spectrum of antibiotic bioactivity compared to the natural product. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.本文提供抗菌化合物，其中該化合物在一些具體例中具廣效性生物活性。本文提供之化合物可在其他具體例中克服由在細菌訊息肽酶(SPases)之固定位置上之單一胺基酸突變所造成之抗藥性，及在其他具體例中提供相較於天然物為更廣效性之抗生素生物活性。也提供藥學組成物及使用本文所述化合物之用於治療的方法。
