Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.本文提供抗菌化合物,其中,在一些具體例中,該等化合物具有廣效生物活性。在其他具體例中,本文提供之化合物可以在克服細菌性訊息肽酶(SPase)之界定位置上單一胺基酸突變所導致之抗藥性,而在其他具體例中,提供廣效之抗生素生物活性。同時,本文提供使用本文所述化合物之醫藥組合物和治療方法。
