巨環廣效抗生素农业专利-农业学术服务平台

发明人:: ROBERTS, TUCKER CURRAN,罗伯兹　塔克　克伦,羅伯茲　塔克　克倫,SMITH, PETER ANDREW,史密斯　彼德　安德鲁,史密斯　彼德　安德魯,HIGUCHI, ROBERT I.,希古奇　罗伯特Ｉ,希古奇　羅伯特Ｉ,CAMPBELL, DAVID,坎贝尔　大卫,坎貝爾　大衛,PARASELLI, PRASUNA,帕拉赛利　普拉苏纳,帕拉賽利　普拉蘇納,罗伯兹塔克克伦,羅伯茲塔克克倫,史密斯彼德安德鲁,史密斯彼德安德魯,希古奇罗伯特I,希古奇羅伯特I,坎贝尔大卫,坎貝爾大衛,帕拉赛利普拉苏纳,帕拉賽利普拉蘇納

摘要：: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.本文提供抗細菌化合物，其中該等化合物在一些實施例中具有廣效生物活性。在各種實施例中，該等化合物藉由抑制細菌中一種必不可少之蛋白質細菌1型信號肽酶(SpsB)來起作用。還提供使用本文所述之化合物的醫藥組合物及治療方法。