The present invention relates to the substituted-amino oxinanes of novel structural formula I, are the inhibitor of dipeptidyl peptidase-IV enzyme and the treatment or prevention that can use what disease related with dipeptidyl peptidase-IV enzyme, such as diabetes and especially diabetes B. The invention further relates to the purposes comprising the pharmaceutical composition of these compounds and these compounds and composition in the prevention or treatment of this kind of disease related with dipeptidyl peptidase-IV enzyme.本發明涉及新穎的結構式I的取代氨基四氫吡喃，其為二肽基肽酶-IV酶的抑制劑並且可以用於與二肽基肽酶-IV酶有關的疾病的治療或預防，例如糖尿病並且特別是2型糖尿病。本發明還涉及包含這些化合物的藥物組合物，以及這些化合物和組合物在與二肽基肽酶-IV酶有關的這類疾病的預防或治療中的用途。
