The present invention relates to certain spirocyclic compounds that are inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 (11βHSD1), compositions containing the same, and methods of using the same for the treatment of diabetes, obesity and other diseases.本發明係關於作為11-β羥基類固醇脫氫酶第一型(11βHSD1)之抑制劑的某些螺環化合物、含有該等化合物之組合物及使用其治療糖尿病、肥胖症及其他疾病之方法。