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Polymer conjugate vaccine
专利权人:
ザ・ユニバーシティ・オブ・シカゴ
发明人:
ハッベル ジェフリー エイ.,ウィルソン デイビッド スコット,廣末 幸子
申请号:
JP2018536089
公开号:
JP2018531318A6
申请日:
2016.09.29
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
Monomer and copolymer, as long as the APCs of two target antigen presenting cells (APCs) and toll-like receptor activation (TLR). In some embodiments, composition and method are related to that target mannose receptor of polymer to APCs, in addition to activating TLR. Then,Efficiently to the costimulatory molecules of DCs inducible up regulation while these arrive proteantigen to target antigen by conjugation, that is to realize effective t cell activation. The DCs of the more effective activator of the copolymer uses polymer formulations than the tlr agonist monomeric forms if measurement is by expressing costimulatory molecules, and release proinflammatory cytokine. It is related to new compound in terms of the disclosure and composition is used to treat the copolymer and composition as described herein using the compound.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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