Alex KARLSSON-PARRA,AnnaCarin WALLGREN,Bengt ANDERSSON
申请号：
US14164518
公开号：
US20140141046A1
申请日:
2014.01.27
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a method for the production of a cellular allogeneic vaccine, which is based upon an allogeneic APC, comprising the following steps:isolation of an APC from a subject or providing an APC already established and/or isolated from a myeloid leukemia cell line, andmodifying the APC with an antigen using any of the following methods: pulsing, transfection, infection or fusion；treatment using an agent capable of removing sialic acid on cell surfaces； and optionallyculturing the APC in a suitable medium,an allogeneic vaccine obtainable by the above method, a composition comprising said vaccine and a pharmaceutically acceptable carrier and therapeutic use of said vaccine or said composition.
