Karl John Sanford;Richard R. Bott;David Aaron Estell;John Bryan Jones;Benjamin G. Davis
发明人:
Benjamin G. Davis,John Bryan Jones,Richard R. Bott,Karl John Sanford,David Aaron Estell
申请号：
US12953378
公开号：
US08431121B2
申请日:
2010.11.23
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.
