Steven D. Levin;George Robert Mabry, III;Monica J. Huber;Katherine E. Lewis;Scott R. Presnell;Stephen R. Jaspers
发明人:
Katherine E. Lewis,Scott R. Presnell,Steven D. Levin,George Robert Mabry, III,Stephen R. Jaspers,Monica J. Huber
申请号：
US13032501
公开号：
US08333968B2
申请日:
2011.02.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
