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Polynucleotides encoding antagonists of IL-17A, IL-17F, and IL-23p19
专利权人:
ZymoGenetics; Inc.
发明人:
Katherine E. Lewis,Scott R. Presnell,Steven D. Levin,Robert Mabry,Stephen R. Jaspers,Monica J. Huber
申请号:
US14626959
公开号:
US09464134B2
申请日:
2015.02.20
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
来源网站:
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来源网址:
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