GENENCOR INTERNATIONAL, INC.;THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
发明人:
申请号：
EP00928344.1
公开号：
EP1185302B1
申请日:
2000.04.21
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
This invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.
