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PROTEASE-RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN THE REPAIR OF TISSUE DAMAGE
专利权人:
Mesoblast International Sàrl
发明人:
Vincent Frans Maria SEGERS,Anthony SANDRASAGRA,Yan QIU
申请号:
US15054456
公开号:
US20160375100A1
申请日:
2016.02.26
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention features mutant stromal cell derived factor-1 (SDF-1) peptides that have been mutated to make them resistant to digestion by, for example, the proteases dipeptidyl peptidase IV (DPPIV), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), leukocyte elastase, cathepsin G, carboxypeptidase M, and carboxypeptidase N, but which retain chemoattractant activity.
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中国工程科技知识中心
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