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1, 2, 4-triazole derivatives and their anti mycobacterial activity
专利权人:
Dhiman Sarkar
发明人:
Dhiman Sarkar,Sunita Ranjan Deshpande,Shailaja Pramod Maybhate,Anjali Prabhakar Likhite,Sampa Sarkar,Arshad Khan,Preeti Madhukar Chaudhary,Sayalee Ramchandra Chavan
申请号:
US13634352
公开号:
US08865910B2
申请日:
2011.03.14
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Invention provides antitubercular compounds selected from propargylated 1,2,3 triazoles of Formula I, wherein, X is sulfur(S) or a sulphone (A), n, m represent independently an integer O or 1, with the provision that when ‘n’ is 1, ‘m’ is 1 R1 is hydrogen C1-C6 linear or branched alkyl group optionally substituted with aryl group halogen or aryl group optionally substituted with —OCH3, halogen, and nitro R2 and R3 are selected from the group consisting of hydrogen, C1-C6 alkyl optionally substituted with heterocyclic ring of 5 to 6 ring atoms containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with alkyl, arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or allyl or propargyl groups consisting of 1 to 6 carbon atoms Z is C1-C6 alkyl optionally substituted with heterocyclic ring of 1 to 6 ring atoms, containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl allyl or propargyl groups consisting of 1 to 6 carbon atoms with the provision that when ‘m’ is 1, and ‘n’ is zero R1 is selected from the group consisting of hydrogen, halogen C1-C6 linear or branched alkyl group optionally substituted with aryl group or aryl group optionally substituted with —OCH3, halogen, and nitro, R2 and R3 are selected from the group consisting of hydrogen, C1-C6 alkyl optionally substituted with heterocyclic ring of 5 to 6 ring atoms containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with alkyl, arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or allyl or propargyl groups consisting of 1 to 6 carbon atoms Z is selected from the group consisting of halogen, C1-C6 linear or branched alkyl group optionally substituted with heterocyclic ring of 1 to 6 ring atoms, containing one t
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