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New pyrrole derivatives, their preparation process and pharmaceutical compositions containing them
专利权人:
Les Laboratoires Servier;Vernalis (R&D) Ltd.
发明人:
Le Tiran, Arnaud,Le Diguarher, Thierry,Starck, Jérôme-Benoît,Henlin, Jean-Michel,Guillouzic, Anne-Françoise,De Nanteuil, Guillaume,Geneste, Olivier,Fejes, Imre,Tatai, Janos,Nyerges, Miklos,Davidson, J
申请号:
ES14178016
公开号:
ES2620515T3
申请日:
2014.07.22
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound of formula (I): ** Formula ** where: - A1 represents a hydrogen or halogen atom, a linear or branched (C1-C6) polyhaloalkyl, a linear or branched (C1-C6) alkyl group or a group cycloalkyl, - A2 represents a linear or branched (C1-C6) alkyl group optionally substituted with a group selected from halogen, hydroxy, linear or branched (C1-C6) alkoxy, NR'R '' and morpholine, or A2 represents a linear or branched (C1-C6) polyhaloalkyl or a cyclopropyl group, it being understood that R 'and R' 'independently represent each other, a hydrogen atom or a linear or branched (C1-C6) alkyl group, - T represents an atom of hydrogen, linear or branched (C1-C6) alkyl optionally substituted with one to three halogen atoms, (C1-C4) alkyl-NR1R2, or a (C1-C4) -OR6 alkyl group, -R1 and R2 independently represent each other, a hydrogen atom or a linear or branched (C1-C6) alkyl group, or R1 and R2 form, together with the atom of nitrogen that carries them, a heterocycloalkyl, - R3 represents an aryl or heteroaryl group, it being understood that one or more of the carbon atoms of the above groups or their possible substituents may be deuterated, - R4 represents a phenyl group, 4- hydroxyphenyl, 3-fluor-4-hydroxyphenyl, 2-hydroxypyrimidine or 3- hydroxypyridine, it being understood that one or more of the carbon atoms of the above groups or of their possible substituents may be deuterated, - R5 represents a hydrogen atom or of halogen, a linear or branched (C1-C6) alkyl or a linear or branched (C1-C6) alkoxy group, - R6 represents a hydrogen atom or a linear or branched (C1-C6) alkyl group, - Ra and Rd they represent in each case a hydrogen atom and (Rb, Rc) form, together with the carbon atoms that carry them, a 1,3-dioxolane group, a 1,4-dioxane group, or Ra, Rc and Rd represent in each case a hydrogen atom and Rb represents a hyd atom halogen or halogen or a methoxy group, or Ra and Rd each represent a hydrogen atom, Rb represents a hydrogen or halogen atom and Rc a hydroxy or m
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