LE TIRAN, Arnaud,LE DIGUARHER, Thierry,STARCK, Jérôme-Benoît,HENLIN, Jean-Michel,DE NANTEUIL, Guillaume,GENESTE, Olivier,DAVIDSON, James Edward Paul,MURRAY, James Brooke,CHEN, I-Jen
申请号：
ES14758605
公开号：
ES2650814T3
申请日:
2014.07.22
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Compound of formula (I): ** Formula ** where: - X and Y represent a carbon atom or a nitrogen atom, it being understood that they cannot simultaneously represent two carbon atoms or two nitrogen atoms, - the Het part of the group represents an optionally substituted ring, aromatic or not, formed by 5, 6 or 7 ring members, and may contain, in addition to the nitrogen represented by X or Y, from 1 to 3 heteroatoms independently selected from oxygen, sulfur or nitrogen, it being understood that the nitrogen in question may be substituted with a group representing a hydrogen atom, a linear or branched (C1-C6) alkyl group or a -C (O) -O-Alk group, where Alk is an alkyl group ( C1-C6) linear or branched, - T represents a hydrogen atom, a linear or branched (C1-C6) alkyl optionally substituted with one to three halogen atoms, a (C2-C4) -NR1R2 alkyl group, or a group (C1-C4) alkyl -OR6, - R1 and R2 represent, independently In each other, a hydrogen atom or a linear or branched (C1-C6) alkyl group, or R1 and R2, together with the nitrogen atom that carries them, form a heterocycloalkyl, - R3 represents a (C1-C6) alkyl group ) linear, aryl or heteroaryl, these last two groups being able to be substituted with one to three groups selected from halogen, linear or branched (C1-C6) alkyl, linear or branched (C1-C6) alkoxy, cyano and heterocycloalkyl-C1 alkyl -C6) linear or branched, it being understood that one or more carbon atoms of the preceding groups, or of their eventual substituents, may be deuterated, - R4 represents a 4-hydroxyphenyl group, it being understood that one or more of the carbon atoms of the group, or of its possible substituents, may be deuterated, - R5 represents a hydrogen or halogen atom, a linear or branched (C1-C6) alkyl group or a linear or branched (C1-C6) alkoxy group, - R6 represents a hydrogen atom or an alkyl group ( C1-C6) linear or branched, - Ra and Rd represent in each case a hydrogen atom and (Rb, Rc), together with the carbon atoms that carr
