KONETZKI, Ingo,JAKOB, Florian,CRAAN, Tobias,HESSLINGER, Christian,RATCLIFFE, Paul,NARDI, Antonio
申请号：
ES14718916
公开号：
ES2642822T3
申请日:
2014.04.15
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Pyrimidine compounds of the general formula (I) ** (See formula) ** where G is a phenyl optionally substituted with at least one Z substituent or a 5 or 6 membered aromatic heterocycle optionally substituted with at least one Z substituent, which may be said phenyl or said aromatic heterocycle condensed with a 4, 5, 6 or 7-membered ring, said condensed ring being able to be saturated, partially unsaturated or aromatic, and substituted with at least one Z substituent； Z is, independently of one another, (C1-C6) alkyl, hydroxyalkyl (C1-C6), alkoxy (C1-C6), haloalkyl (C1-C6), haloalkoxy (C1-C6), -S-alkyl (C1-C6) ), halogen, hydroxyl or cyano, or is SO2-C1-C6 alkyl, CONH2, NHSO2-C1-C6 alkyl, NHCO-C1-C6 alkyl, where the alkyls mentioned are linear or branched and may be substituted； T is CR1R2 or S (O) x or S (O)>； = NH； x is 0, 1 or 2； R1 and R2 are, independently of each other, hydrogen, (C1-C6) alkyl, preferably (C1-C4) alkyl, (C1-C6) alkoxy, preferably (C1-C4) alkoxy, (C1-C6) haloalkyl, where The mentioned alkyl chains are linear or branched and may be substituted； n is 1 or 2； K is (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, halogen, hydroxyl or cyano, wherein the mentioned alkyl chains are linear or branched and may be substituted； M is 0, 1, 2, 3 or 4； X is, independently of one another (C1-C6) alkyl, cycloalkyl (C3-C6), alkoxy (C1-C6), cycloalkoxy (C3-C6), haloalkyl (C1-C6), haloalkoxy (C1-C6), halogen, hydroxyl, cyano, carboxyl, C (O) -NH2, C (O) -NH (C1-C6) alkyl, C (O) -N ((C1-C6) alkyl) 2, NH2, NH-C1-alkyl C6), N ((C1-C6) alkyl) 2, N-pyrrolidinyl, Npiperidinyl, N-morpholinyl, NH-CHO, NH-C (O) -alkyl (C1-C6), S (O) 2-NH2, S-C1-C6 alkyl, S (O) -C1-C6 alkyl, S (O) 2-C1-C6 alkyl, O-C1-C4 alkyl-CN, O-C1 alkyl -C4) -NH-CHO, O-(C1-C6) alkyl - NH-C (O) -alkyl (C1-C6) or O-alkyl (C1-C4) -N ((C1-C6) alkyl) 2 , or is O-C1-C4 alkyl-O-C1-C4 alkyl, where the aforementioned alkyl chains are linear or branched and may be substituted, or it is a chemical grouping L-CO
