Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof

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专利权人:

Lexicon Pharmaceuticals Inc.

发明人:

Carson Kenneth Gordon,Cianchetta Giovanni,Bi Yingzhi,Green Michael Alan,Kumi Godwin,Liang Zhi,Liu Ying Jade,Main Alan,Zhang Yulian,Zipp Glenn Gregory

申请号：

NZ63071913

公开号：

NZ630719A

申请日:

2013.03.05

申请国别(地区):

NZ

年份:

2017

代理人:

摘要：

Imidazo[1,2-b]pyridazine-based compounds of the formula (I): are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed. An example of the compound is (S)-1-(2-(((3-(3-chlorophenyl)imidazo[1,2-b] pyridazin-6-yl)amino)methyl)pyrrolidin-1-yl)-3-methylbutan-1-one.

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中国工程科技知识中心

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http://www.ckcest.cn/home/