As for this invention, the closed space, for example the medicine manufacture clean room, it regards the improvement in the manner which controls the biological decontamination cycle which is used for the biological decontamination of the isolator and the ward. As for biological decontamination cycle, the sterilization medicine steam to be generated inside the closed space, it possesses the multiple phases which at least include one which can be wrapped gas treatment phase. As for manner, continuing the adjustment relative humidity of the air inside the closed space, being the process which it measures, as for adjustment relative humidity, [water and sterilization medicine steam]: [The process which is water in air and ratio of capacity of sterilization medicine steam], and using the adjustment relative humidity which was measured, it is characterized by the process which controls the process of process.本発明は、閉鎖空間、例えば製薬クリーンルーム、アイソレータおよび病棟の生物学的除染のために使用される生物学的除染サイクルを制御する方法における改善に関する。生物学的除染サイクルは、滅菌剤蒸気が閉鎖空間内で発生させられ、循環させられる少なくとも1つのガス処理相を含む複数の相を有する。方法は、閉鎖空間内の空気の修正相対湿度を連続して測定する工程であって、修正相対湿度は、[水および滅菌剤蒸気]:[空気中の水および滅菌剤蒸気の容量]の比である工程、および測定された修正相対湿度を使用してプロセスの工程を制御する工程により特徴づけられる。
