YOU, JHONG JHE,游忠哲,HSU, CHING HSUAN,徐静轩,徐靜軒,HUANG, PO LIN,黄柏霖,黃柏霖,HER, JENG-HORNG,何正宏
申请号：
TW108106894
公开号：
TW201945023A
申请日:
2019.02.27
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
Provided are bispecific proteins that comprise a binding domain binding cell surface protein and a vascular endothelial growth factor (VEGF) inhibiting domain. Provided also is an antibody-drug conjugate that comprises a therapeutic agent and an antibody or an antigen-binding fragment binding PD-L1 and/or a VEGF inhibiting domain, wherein the therapeutic agent is covalently conjugated to the antibody or the antigen-binding fragment by a linker.提供一種雙特異性蛋白質，包含結合細胞表面蛋白的結合區、以及血管內皮生長因子抑制區。另提供一種抗體藥物複合體，包含治療試劑以及抗體或抗原結合片段，結合至PD-L1及/或血管內皮生長因子抑制區，其中治療試劑藉由連接子與抗體或抗原結合片段共價接合。
