The present disclosure relates to antibody binding to human IL-4R, antigen-binding fragment thereof and medical use thereof. Further, the present disclosure relates to a chimeric antibody, a humanized antibody comprising CDR regions derived from the antibody that binds human IL-4R and an antigen-binding fragment thereof, and also relates to a pharmaceutical composition comprising the antibody that binds human IL-4R and an antigen-binding fragment thereof, as well as their use as a medicament for treating an allergic disease. In particular, the disclosure relates to the use of a humanized antibody that binds to human IL-4R for the preparation of a medicament for the treatment of an IL-4R mediated disease or condition.本公開涉及結合人IL-4R的抗體、其抗原結合片段及其醫藥用途。進一步地，本公開涉及一種嵌合抗體、人源化抗體，其包含來自前述結合人IL-4R的抗體及其抗原結合片段的CDR區，以及還涉及包含前述結合人IL-4R的抗體及其抗原結合片段的醫藥組成物，及其作為治療過敏性疾病藥物的用途。尤其地，本公開涉及一種人源化的結合人IL-4R的抗體，在製備用於治療IL-4R介導的疾病或病症的藥物中的用途。
