The present invention relates to a B7-H3 antibody or antigen-binding fragments thereof, and pharmaceutical use thereof. Further, the present invention relates to a a pharmaceutical composition comprising the present B7-H3 antibody and the antigen-binding fragments thereof, and their use as drugs. In particular, the present invention relates to a human B7-H3 antibody or antigen-binding fragments thereof, and its use in preparation of a medicament for the treatment of B7-H3 mediated disease or disorder.本發明涉及B7-H3抗體、其抗原結合片段及其醫藥用途。進一步地，本發明涉及包含B7-H3抗體或其抗原結合片段的醫藥組成物，以及其作為藥物的用途。特別地，本發明涉及一種人B7-H3人抗體或其抗原結合片段在製備用於治療B7-H3相關的疾病或病症的藥物中的用途。
