The present invention relates to the technical field of antibody medicines, in particular to an anti-CD47 antibody or an antigen-binding fragment thereof, a pharmaceutical composition containing an anti-CD47 antibody or an antigen-binding fragment thereof, and their applications. The anti-CD47 antibody or antigen-binding fragment thereof of the present invention has significant anti-tumor activity, has a high affinity with human CD47 protein, can block the ability of SIRPa to bind to CD47 on the cell surface, and does not have significant hemagglutination activity. Application in the preparation of anti-tumor drugs.本發明涉及抗體藥物技術領域，尤其涉及一種抗CD47抗體或其抗原結合片段，包含抗CD47抗體或其抗原結合片段的藥物組合物以及它們的應用。本發明的抗CD47抗體或其抗原結合片段具有顯著的抗腫瘤活性，與人CD47蛋白的親和力較高，可阻斷SIRPa結合到細胞表面CD47的能力，且不具有顯著的紅血球凝集活性，可在製備抗腫瘤的藥物中應用。
