The present application provides an antibody, such as a monoclonal antibody (mAb), or an antigen binding fragment thereof, that specifically recognizes TIGIT. Also provided are pharmaceutical compositions, or methods of making and using the antibody or antigen-binding fragment thereof.本申請提供一種特異性識別TIGIT之抗體諸如單株抗體(mAb)或其抗原結合片段。亦提供醫藥組成物、或製備及使用該抗體或其抗原結合片段之方法。