The present invention relates to anti-CD27 antibody, antigen-binding fragments, and pharmaceutical use thereof. Furthermore, the present invention relates to chimeric and humanized antibodies comprising the CDR regions of the present anti-CD27 antibody, as well as pharmaceutical compositions comprising the present anti-CD27 antibody and antigen-binding fragments thereof, and their use as anticoagulant drugs. In particular, the present invention relates to the use of a humanized anti-CD27 antibody in the manufacture of a medicament for the treatment of CD27-mediated disease.本發明涉及抗CD27抗體、其抗原結合片段及其醫藥用途。進一步地，本發明涉及包含該抗CD27抗體CDR區的嵌合抗體、人源化抗體，以及包含人抗CD27抗體及其抗原結合片段的醫藥組成物，以及其作為抗癌藥物的用途。尤其地，本發明涉及一種人抗CD27抗體及其在製備用於治療CD27介導的疾病或病症的藥物中的用途。
