DOMINIQUE BERNARD,AGNES THOMAS COLLIGNON,ROGER ROZOT,BENOIT MULLER
申请号：
FR1060182
公开号：
FR2968200B1
申请日:
2010.12.07
申请国别(地区):
FR
年份:
2013
代理人:
摘要：
Cosmetic use of at least one thiophene compounds (I) and their salts, as an active agent for treating and/or preventing a cosmetic defect of the skin and/or of its annexes linked to an imbalance in the differentiation and/or the proliferation of cells of an epidermis, is claimed. Cosmetic use of at least one thiophene compounds of formula (I) and their salts, as an active agent for treating and/or preventing a cosmetic defect of the skin and/or of its annexes linked to an imbalance in the differentiation and/or the proliferation of cells of an epidermis, is claimed. n : 0 or 1； X : O or NH； either R1, R2 : H, -OH, -NH 2, F, 1-5C alkyl (optionally saturated and optionally interrupted by at least one heteroatoms of O, N or S), optionally saturated 5-10C cycloalkyl, or optionally saturated 5-10-membered ring comprising at least one heteroatoms of O, N or S； or R1R2 : optionally saturated 5-10 membered ring (optionally comprising at least one heteroatoms of O, N or S)； R3 : H, -OH, -NH 2, F, optionally saturated 1-5C alkyl, optionally saturated 5-10C cycloalkyl, 5-10-membered ring (optionally saturated and comprising at least one heteroatom of O, N or S), -OR11, -R11OH, -C(O)R11, -OC(O)R11, -C(O)OR11, -C(O)NH 2, -C(O)NH-R11, -C(O)NHR11R12, or NR11R12； R11, R12 : 1-5C alkyl (optionally saturated and optionally interrupted by at least one heteroatoms of O, N or S)； either R4 : H, -OH, -NH 2, F, optionally saturated 1-5C alkyl, -OR13, -R13OH, -C(O)R13, -OC(O)R13, -C(O)OR13, -C(O)NH 2, or -C(O)NH-R13； and R5 : H, -OH, -NH 2, F, optionally saturated 1-5C alkyl, -OR13, -R13OH, -C(O)R13, -OC(O)R13, -C(O)OR13, -C(O)NH 2, -C(O)NH-R13, or -(Y1) m-ZR14； or R4R5 : 3-8C cycloalkylene group； R13 : 1-5C alkyl group； and R6-R10 : H, -OH, -NH 2, fluorine, optionally saturated 1-5C alkyl, optionally saturated 5-10C cycloalkyl, -OR13, -R13OH, -C(O)R13, -OC(O)R13, -C(O)OR13, -C(O)NH 2, or -C(O)NH-R13. Independent claims are included for: (1) pharmaceutical or dermatological composition com
