Dihydrothienopyrimidine derivatives (I) are new. Dihydrothienopyrimidine derivatives of formula (I) and their salts, diastereomers, enantiomers, racemates, hydrates or solvates are new. X : O, S, SO or SO 2； either R 1>； : H, 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 6-10C aryl or 6-10C aryl-1-6C-alkylene, 5-10C heteroaryl-1-6C-alkylene； and R 2>； : 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl (all optionally substituted), optionally one or more bridged mono- or bicyclic 3-10C cycloalkyl, 6-10C aryl, aromatic or non-aromatic, 3-10C heterocyclic ring, a bicyclic ring or 3-10C heterocycle condensed 6-10C aryl, or H； or NR 1>；R 2>； : heterocyclic ring, optionally with one or more of 1-4C-alkyl, 2-6C-alkenyl, 2-6C-alkynyl, 1-6C alkanol or oxo； R 3>； : 6-10C heterocyclic ring, 3-7C cycloalkyl, 6-10C aryl-1-6C alkylene, 5-10C heteroaryl-1-6C-alkylene, a condensed bicyclic ring (optionally containing 1-4 heteroatoms of N, O or S), optionally substituted phenyl, COR 37>；, COCH 2R 38>；, CONHR 38>； or SO 2R 38>；； R 37>； : H, 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl or 6-10C aryl； R 38>； : 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 3-7C cycloalkyl, 6-10C aryl, 3-10C heterocyclic ring and a bicyclic ring, optionally substituted with one or more of 1-6C-alkyl, 2-6C alkenyl, 2-6C alkynyl, halo, NR-38aR-38b, 6-10C aryl or 3-10C heterocyclic ring； R-38a, R-38b : H, 1-6C alkyl, 2-6C alkenyl or 2-6C alkynyl； R 4>； : H, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl or oxo； R 5>；, R 6>； : H, 1-4C alkyl, 2-4C alkenyl or 2-4C alkynyl； and either R 7>；, R 8>； : H, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, 6-10C aryl or OH； or R 7>；+R 8>； : oxo. An independent claim is included for 50 intermediate compounds e.g. pyrimidine derivatives of formula (VIII), (IV) or (V). [Image] [Image] ACTIVITY : Respiratory-Gen.； Gastrointestinal-Gen.； Antiinflammatory； Cytostatic； CNS-Gen.； Antiasthmatic； Antiulcer.Antidepressant； Neuroleptic； Antimanic； Neuroprotective； Nootropic； Antiparkinso
