YALE UNIVERSITY;REGENERON PHARMACEUTICALS, INC.;INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB)
发明人:
GEORGE D. YANCOPOULOS,ANDREW J. MURPHY,SEAN STEVENS,RICHARD FLAVELL,ELIZABETH EYNON,MARKUS G. MANZ,JORGE GALAN,TIM WILLINGER,ANTHONY RONGVAUX
申请号：
PT16157878
公开号：
PT3056082T
申请日:
2010.10.04
申请国别(地区):
PT
年份:
2018
代理人:
摘要：
A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene； and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a yeloproliferative neoplasia.
