МАКДОНАЛД Линн (US),МАКУИРТЕР Джон (US),ГЮРЕР Каган (US),ХОСИАВА Каролина А. (US),МЕРФИ Эндрю Джей (US)
申请号：
RU2014118869/10
公开号：
RU2014118869A
申请日:
2012.10.17
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A mouse comprising a limited immunoglobulin heavy chain locus, characterized by the presence of a single gene segment Vcheloveka, one or more gene segments Dcheloveka and one or more gene segments Jcheloveka, wherein only Vcheloveka gene segment is a polymorphic gene segment V.2. A mouse according to claim. 1, comprising a deletion of all or substantially all of the endogenous gene segments V, D and J.3. A mouse according to claim. 1, in which a single gene segment is selected from Vcheloveka V1-2, V1-69, V2-26, V2-70 and V3-23.4. A mouse according to claim. 3, in which a single gene segment Vcheloveka represents V1-69.5. A mouse according to claim. 3, in which a single gene segment Vcheloveka represents V1-2.6. A mouse according to claim. 1, in which a single gene segment Vcheloveka operably linked to a human or non-human constant region gene immunoglobulina.7. A mouse according to claim. 6, in which the immunoglobulin constant region gene is a gene of the constant region of mouse, rat or cheloveka.8. The mouse of Claim. 1 further comprising one or more gene segments of human Vimmunoglobulina operably associated with one or more gene segments Jcheloveka.9. A mouse according to claim. 8, in which one or more gene segments Vcheloveka and / or one or more gene segments selected from Jcheloveka gene segments κ and λ cheloveka.10. A mouse according to claim. 8, in which one or more gene segments Vimmunoglobulina human and one or more gene segments Jcheloveka operatively associated with non-human constant region gene tsepi.11 light. mouse of claim. 10, in which the non-human constant region gene1. Мышь, содержащая ограниченный локус тяжелой цепи иммуноглобулина, характеризующийся наличием единственного генного сегмента VH человека, одного или нескольких генных сегментов DH человека и одного или нескольких генных сегментов JH человека, причем единственный генный сегмент VH человека представляет собой полиморфный генный сегмент VH.2. Мышь по п. 1, содержащая делецию все
