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GENETICALLY MODIFIED MOUSE WHOSE GENOME COMPRISES A HUMANIZED CD274 GENE
专利权人:
发明人:
Elena Burova,Yajun Tang,Ka-Man Venus Lai,Andrew J. Murphy
申请号:
US15883477
公开号:
US20180160663A1
申请日:
2018.01.30
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Non-human animals, methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a Cluster of Differentiation 274 (CD274) gene. Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous CD274 gene so that said non-human animals express a Programmed cell death ligand 1 (PD-L1) polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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